The Nerazzurri come into this clash in particularly high spirits, having won each of their last six fixtures in all competitions.
Having won just one of the last six derby games though, they are 7/5 (2.40) favourites with bet365 to regain bragging rights by coming out on top here.
However, Gennaro Gattuso's men are also full of confidence after going eight matches without defeat, and can be backed at 21/20 (3.10) to secure their first 'away' win over their neighbours since 2010.
Four of the last five encounters between this pair have resulted in draws, and you can get odds of 9/4 (3.25) on this one also finishing up all square.
With Sime Vrsaljko back at full fitness, Luciano Spalletti has the luxury of a full squad to choose from.
Similarly, long term absentee Ivan Strinic is the only player missing from the Rossoneri first team squad.
Although both won their last major trophy way back in 2011, meetings between these two giants are still highlights of the Italian season.
Entertainment is never far off when the pair clash, with three of the last four Serie A encounters producing at least four goals and the other seeing Mauro Icardi miss two open goals plus a goal ruled out by VAR back in April.
However, Icardi will be confident of atoning for those misses after scoring five goals in his last six matches, while an opposition attack spearheaded by Gonzalo Higuain is averaging over two goals per match this campaign.
All in all, odds of 10/11 (1.91) seem generous on another entertaining derby clash producing over 2.5 goals, in a bet that would have paid out in three of Inter's last four games and four of Milan's last five in the league.