The Terriers have won just one of their last eight matches in all competitions but David Wagner's side will hope that home advantage proves pivotal against the Reds on Tuesday night.
Liverpool's 14-match unbeaten run in the Premier League ended last Monday before they crashed out of the FA Cup against West Bromwich Albion at the weekend.
Despite that, Jurgen Klopp's charges are chalked up as a 1/3 (1.33) with Betfair Sportsbook chance to take all three points against the Terriers.
Huddersfield have failed to win any of their last five fixtures on their own patch and they can be backed at 17/2 (9.50) to claim a vital victory, while the same firm go 4/1 (5.0) that the match ends all square.
Adam Lallana missed Liverpool's FA Cup clash against West Bromwich Albion at the weekend and the England midfielder is a major doubt here.
The hosts have no fresh concerns, but Elias Kachunga remains a long-term absentee.
Reds amongst the goals again?
Before being stunned by Swansea, Liverpool had managed 24 goals in their previous seven away matches.
Huddersfield, however, have drawn a blank in three of their last four Premier League fixtures and it is just 10/11 (1.91) that Wagner's charges fail to find the net against the Reds, or 11/10 (2.10) that Liverpool win to nil.
Tips and predictions
Liverpool's defensive frailty was exposed once again at the weekend and they have now managed just one clean sheet in their last eight games.
The Reds, though, boast real quality in the final third and that should prove to be the difference on this occasion.
Klopp's men are available at even money (2.0) with Betfair Sportsbook (-1) to beat the handicap mark, which could well pay dividends on Tuesday night.
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