The Amakhosi playmaker will face Lidoda Duvha for the first time since leaving the club for Premier Soccer League (PSL) side Baroka FC prior to the start of last season.
Leopards are now campaigning in the PSL after winning last season's PSL Promotional and Relegation play-offs, and they will take on Ntshangase's side in Johannesburg.
"It's going to be an emotional game. I still have some friends at Leopards. However, I am now a Khosi. I want to win trophies and that's why I came to Chiefs," Ntshangase told his club website.
"Leopards will come out all guns blazing because they have nothing to lose. It's an opportunity for the players to shine and be noticed," he continued.
"We respect Leopards, but we will have to look at the bigger picture and that's that. We want to progress to the quarterfinals of the Telkom Knockout," Ntshangase explained.
Amakhosi are heading into the encounter on the back of a Macufe Cup win after beating Bloemfontein Celtic 2-0 at the Free State Stadium last weekend.
"We took a lot of positives out of that Macufe Cup game against Bloemfontein Celtic, and we have been working hard at training to further improve," he added.
"I am sure our supporters will be there and be our 12th man, because we are playing good football. To be honest, we haven't even reached our best yet," he concluded.
Ntshangase has made 12 appearances in all competitions for Amakhosi this season.