Pep Guardiola's men are currently two points adrift of leaders Liverpool, although do boast a game in hand.
Having won 10 and lost none of the last 13 encounters with this opposition, they are overwhelming 1/7 (1.14) favourites with bet365 to move back into pole position by coming out on top once again.
The Cottagers have lost 11 of their last 12 fixtures in all competitions, and are hefty 16/1 (17.00) outsiders to pull off a shock win against the champions, or priced at 13/2 (7.50) to hold them to a draw.
Alfie Mawson and Marcus Bettinelli remain long term absentees, while Andre Schurrle will face a late fitness test after missing the last month due to a virus.
John Stones, Kevin De Bruyne and Fernandinho could all be set for comebacks, although Nicolas Otamendi, Fabian Delph and Benjamin Mendy are still doubtful.
Although results have not improved since Claudio Ranieri's dismissal at the end of February, caretaker boss Scott Parker has at least seen his side put up a decent fight in the last couple of matches.
Indeed, they came from behind to be level against both Leicester and Liverpool recently, only to succumb to goals in the last 15 minutes in 3-1 and 2-1 defeats.
The Citizens may have to show similar persistence in their pursuit of three precious points, having struggled to break the deadlock prior to half-time on the road recently.
With 11 of their last 12 away goals coming after the break, odds of 10/11 (1.91) offer solid value on City ensuring the majority of the goalmouth action unfolds in the second period for their sixth and Fulham's third game in a row.
Odds correct at the time of writing. Please gamble responsibly.