The Brazilians went into the second leg holding a 1-0 lead from the first leg, but Wydad scored through Saidi to level the aggregate scoreline.
It was a surprising defeat for the holders as the majority of South African football fans had hoped they will win and book a place in the semi-finals.
What left the fans buffled was the way Sundowns took their penalties during the shoot-out.
Poor penalty kicks by Mamelodi Sundowns— Setshogo Tumelo (@tumelosetshogo) September 23, 2017
Mamelodi Sundowns penalties 🤷🏿♂️— Sisou (@Sisou_10) September 23, 2017
What's wrong with these fellas manje?
Mamelodi Sundowns... pic.twitter.com/mWysw8WJoR— Mercedes P. Magwai (@Phuttym19) September 23, 2017
However, some are still proud of the Tshwane giants despite the defeat.
Mamelodi Sundowns we Love You.— Des Builder (@DesBuilder6) September 23, 2017
Mamelodi Sundowns tried though #CAFCL— IG:crisis_rsa (@Crisis_RSA) September 23, 2017
Unfortunately we did not make it this time to the finals. It's back to PSL. Hardluck Masandawana, next time.— Mamelodi Sundowns FC (@Sundowns_Fans) September 24, 2017
As expected, Sundowns rivals back home were happy to see them bow out of the competition, especially Orlando Pirates fans.
Mamelodi Sundowns really believed they would get a second star before us... pic.twitter.com/UveCDmWwt1— 🐐Mr Nkosi🐐 (@great_dlamini) September 24, 2017
Mamelodi Sundowns pic.twitter.com/4jfaNucRHv— Onregeerbaar 🇿🇦 (@Kvtlego) September 24, 2017
Mamelodi Sundowns we hav not forgotten dat last yearu got backdoor entrance twice until u win CAF championships. Lightning wont strike twice— Pule Matlho (@PuleMatlho) September 24, 2017