Pep Guardiola's men can move back to the top of the Premier League table with victory in south London. The odds compilers offer just 3/10 (1.30) that City claim all three points against the Eagles.
Roy Hodgson's side, though, will provide a stern test. Palace held City to a 0-0 draw at Selhurst Park last season and the Eagles have a spring in their step after a vital victory against Newcastle United last time out.
Given they won the previous meeting between the pair, the hosts may attract support at 17/2 (9.50) with bet365 as they bid to derail City's quest for back-to-back Premier League titles with another win this weekend. The same firm go 17/4 (5.25) that both sides are forced to settle for a share of the spoils.
Mamadou Sakho and James Tomkins are enforced absentees for the hosts. Max Meyer will be assessed.
The men from Manchester will have to overturn a 1-0 deficit against Mauricio Pochettino's side if they are to keep their European dreams alive.
Manchester City are the top scoring team in the Premier League this season and Guardiola's men can be backed at 6/5 (2.20) to score more than two goals at Selhurst Park.
The 11/8 (2.38) quote from bet365 for at least four goals to be scored in the game could prove popular. The odds compilers also offer a tempting 6/5 (2.20) that there are more than two goals scored with both teams on target.
A trip to Selhurst Park, sandwiched between two Champions League clashes with Tottenham Hotspur, is not a straightforward assignment for Guardiola's side. It is a test fraught with danger as City pursue the Premier League title.
The south London side have not been anywhere near as prolific as the men from Manchester. That said, the Eagles have found the net in 16 of their last 17 matches in all competitions and Hodgson's side will feel confident of maintaining that scoring streak.
Furthermore, Palace enjoyed a sensational 3-2 victory when they travelled to take on Guardiola's men in Manchester back in December and memories of that match may inspire the south Londoners on Sunday.
As such, bet365's 10/11 (1.91) quote for both teams to score could represent real value for punters and should be backed accordingly.
Odds correct at time of writing. Please gamble responsibly.