Jurgen Klopp's men have lost four of the previous seven Premier League meetings between these teams, although they have come out on top in each of their last three visits to this ground in all competitions.
Having run out 1-0 winners in the reverse encounter back in August, they are priced at 4/9 (1.44) with dabblebet to complete their first league double over this opposition since the 1997-98 season.
Roy Hodgson's side secured a first victory in eight attempts by seeing off Huddersfield Town just before the international break, and can be backed at 6/1 (7.00) to follow that up with yet another shock victory here.
Just one of the last 15 encounters between the sides has resulted in a draw, but you can get odds of 15/4 (4.75) on them cancelling each other out on this occasion.
The Eagles could be without a number of first team players, including Joel Ward, Jason Puncheon, Alexander Sorloth, Jeffrey Schlupp, and Wilfried Zaha.
Joe Gomez is out for the visitors after picking up an injury on international duty, although Dejan Lovren and Emre Can could return and long-term absentee Nathaniel Clyne is nearing full fitness.
Strong Palace record
As well as their poor record against this opposition, the Reds will be particularly wary of slipping up due to the Hodgson factor.
The former Liverpool manager has won three of his last five league encounters against his old side, and boasts a strong home record since taking over at Selhurst Park.
Only Arsenal, Manchester United and Tottenham have left this ground with a victory over the last 13 matches, with the latter two requiring late winners, whilst Manchester City and Chelsea have taken just a point between them.