Steve Agnew's team must win at Stamford Bridge to avoid relegation if Hull City, who have won six and drawn one of their past seven home games, beat bottom-of-the-table Sunderland at the KC Stadium on Saturday.
Chelsea, of course, are looking to take another step towards sealing the league championship by winning a match they will be expected to triumph in comfortably.
|Game||Chelsea vs Middlesbrough|
|Date||Monday, May 8, 2017|
|Time||20:00 GMT, 15:00 ET|
TV CHANNEL & LIVE STREAM
In the UK, the match will be available to watch live on television on Sky Sports 1 and by stream via Sky Go.
|UK TV channel||Online stream|
|Sky Sports 1||Sky Go|
In the US, the match will be available to watch live on television on NBCSN and by stream via NBC Sports Live.
|US TV channel||Online stream|
|NBCSN||NBC Sports Live|
SQUADS & TEAM NEWS
|Goalkeepers||Begovic, Courtois, Eduardo|
|Defenders||Zouma, Cahill, Terry, Azpilicueta, Aina, Alonso, Luiz, Ake|
|Midfielders||Fabregas, Hazard, Matic, Willian, Loftus-Cheek, Moses, Kante, Chalobah, Kenedy|
|Forwards||Pedro, Costa, Batshuayi|
N'Golo Kante and David Luiz are both doubts for Chelsea, with the Brazilian substituted in the win over Everton and the Frenchman also carrying a knock.
Thibaut Courtois, meanwhile, is suffering with an ankle problem but willing to play through the pain for the remainder of the season.
|Goalkeepers||Konstantopoulos, Valdes, Guzan|
|Defenders||Friend, Ayala, Gibson, Bernardo, Barragan, Fabio, Husband, Chambers, Fry|
|Midfielders||Leadbitter, Clayton, Downing, Forshaw, De Roon, Traore, Ramirez, Guedioura|
|Forwards||Stuani, Fischer, Negredo, Gestede, Bamford|
Middlesbrough have no definite absentees but a number of doubts. Victor Valdes continues to struggle with a rib problem, while Gaston Ramirez is likely to miss out with a pelvic injury.
Daniel Ayala will also have an ankle injury assessed but Grant Leadbitter and Adlene Guedioura are back in training and should be available.
BETTING & GAME ODDS
Chelsea are 1/6 favourites to win at home, according to Oddschecker, with Middlesbrough massive outsiders at 22/1 and the draw available at 8/1.
Diego Costa is the 5/2 favourite to score first, with Eden Hazard rated at 4/1. Alvaro Negredo is the top choice for the visitors at 14/1.
It is hard to see Chelsea slipping up here - and extending Middlesbrough's stay in the top flight - unless injuries have a severe impact on Antonio Conte's plans.
There are not many players of greater importance to the Blues than David Luiz and N'Golo Kante, and if they are ruled out it will be interesting to see how the league leaders react.
While their absence would undoubtedly hurt Chelsea over the longer term, though, it is difficult to imagine the likes of Nathan Ake and Cesc Fabregas struggling to cope as their likely replacements in this particular match against the Premier League's 19th-place side.
That is reflected in the huge odds available to back Middlesbrough to win this game - rarely is one Premier League team as long as 22/1 to beat another.
Boro have won just one of their 17 away games so far this season, scoring 10 goals. Anything but a Blues win - and another step towards the title - will represent the shock of the season.