The France captain became the seventh player to reach the landmark, joining company that includes national coach Didier Deschamps and Zinedine Zidane.
Lillian Thuram is the all-time leader in France caps with 142, with Thierry Henry second with 123.
Lloris – who made his debut in 2008 – captained Les Bleus for their 2016 European Championship campaign on home soil, where they were defeated in the final by Portugal, and has played at three World Cups.
France defeated Australia 2-1 in their opening match at the 2018 World Cup and will seal their place in the round of 16 if they beat Peru in Ekaterinburg on Thursday.
While Lloris' 100th cap may have seemed a forgone conclusion just a few months ago, the goalkeeper came under some heat in the lead up to the tournament.
After a season with Spurs that saw him finish tied for second in the Premier League in errors leading to goals , Lloris was hit for criticism in France's friendlies against Italy and the United States for goals conceded.
Against Italy, Lloris parried Mario Balotelli's free-kick back toward the center of the area and right into the path of Leonardo Bonucci, who directed the rebound home.
Then against the USMNT, Lloris was beaten near post on a first-time shot by Julian Green , despite the chance being taken at a narrow angle.
Lloris was handed the start in France's opener against Australia, only conceding the lone Socceroos goal from the penalty spot.