Last week's first leg fixture ended in a 1-1 draw, with Sam Vokes' late goal cancelling out Gary Mackay-Steven's early penalty for the Dons.
As such, it is Sean Dyche's side who hold the advantage, but Derek McInnes' men will still fancy their chances of sending the Clarets crashing out of the competition.
Burnley will progress with a clean sheet, but the men from Lancashire will hope to chalk up a convincing win on home soil and dabblebet go 1/3 (1.34) that the Clarets come out on top.
Aberdeen must score if they are to stand any chance of reaching the next round and dabblebet go 7/1 (8.0) that the Dons triumph at Turf Moor, while the same firm go 7/2 (4.50) that the match ends all square.
Anders Lindegaard came off the bench to replace the injured Nick Pope last week and the veteran Dane could play again, whilst Ashley Barnes, Robbie Brady and Steven Defour all missed last week's tie and remain doubtful.
Tommie Hoban made his Dons' debut against the Clarets and is likely to retain his place after impressing, while Sam Cosgrove is expected to lead the Aberdeen attack at Turf Moor.
Last week's first leg at Pittodrie was a pulsating clash and, with the tie finely poised, both teams could go for glory here.
Burnley, though, will feel confident of making home advantage count when they welcome the Dons to Lancashire.
McInnes' men may struggle to match the intensity that they showed in front of a fervent home support and the Clarets may ease through in relative comfort.
It is, then, the 10/11 (1.91) quote for Burnley to be the only team to score that could represent best value for punters ahead of Thursday's tussle at Turf Moor.