Amakhosi were the first to break the deadlock through Dumisani Zuma, but Victor Letsoalo scored a brace in quick succession to put Celtic in front inside the opening 15 minutes.
Siyabonga Ngezana, Bernard Parker and Ryan Moon settled the encounter with a goal each as Amakhosi won their sixth Macufe Cup title.
Steve Komphela didn't take any chances as he fielded a few of his experienced players, including George Maluleka, Bernard Parker, Willard Katsande and Brilliat Khuzwayo among others for this encounter.
Zuma also cracked the nod against former employers, and it didn't take long before he came back to haunt them. Amakhosi applied the pressure early on, and Zuma found himself in the right place at the right time to put the visitors in front in the 5th minute.
But Amakhosi's defensive fraitalities were again exposed by Letsoalo, who netted twice for Phunya Sele Sele.
Komphela would blame the two goals his side conceded on the fact that he fielded a completely new back four, which was playing together for the first time.
He left out the likes of Erick Mathoho and Lorenzo Gordinho for this clash, with Katsande playing alongside Ngezana in the heart of the Amakhosi defence.
Ngenzana repaid Komphela's faith him by pulling the Soweto giants level midway through the first half. The centre-back fired past Ayanda Mtshali with a powerful header from a Hendrick Ekstein corner in the 20th minute.
While Celtic did well to soak up the pressure with the scoreline at 2-2, it was the visitors who looked comfortable on the ball.
Their dominance paid off in the closing stages of the half, when Parker made it 3-2 with a well-taken header at the far post.
Chiefs lost Kgotso Moleko through injury in the process; the last thing Komphela would need, especially with two crucial league encounters against Mamelodi Sundowns and Orlando Pirates on the horizon for his team.
He would hope Moleko's injury isn't too serious, more so because Ramahlwe Mphahlele is still out injured and the former Celtic man has done well at right-back position since coming on as Rama's replacement.
The Chiefs mentor made wholesale changes at the start of the second half, and it took time for his charges to gel and replicate the first half performance.
However, every Amakhosi fan would be pleased to have seen Joseph Molangoane in action after a two-month absence.
Speculation has been rife regarding the future of the 29-year-old winger at the club, but Komphela has, on numerous occasions, shot down reports of a possible exit for the former Bucs man.
Molangoane hardly put a foot wrong - and probably raised his hand to be selected in the upcoming games.
Celtic for their part, never threatened Chiefs, but they nearly took the game to penalties when a late free-kick attempt came off the woodwork with Khuzwayo, who was a spectator for much of the second period, well beaten.
Moon put the game to bed with a fine penalty deep into stoppage time. This was after Molangoane had been brought down inside the penalty box.
The whole situation was marred by the technical team's decision to order Moon to take the penalty, although Molangoane had kept the ball to indicate that he wanted to take the spot-kick.
That little incident would again raise eyebrows regarding the relationship between Komphela and Molangoane, but only time will tell.