The Red Devils have won both of their games so far and travel to Lisbon looking to keep their 100 per cent record intact.
Doing so would put them at least five points clear of the team in third place in Group A by the end of the matchday.
|Game||Benfica vs Manchester United|
|Date||Wednesday, October 18|
|Time||19:45 BST / 14:45 ET|
TV CHANNEL & LIVE STREAM
In the UK, the match will be available to watch live and for free on television on BT Sport Showcase or by stream via the BT Sport app.
|UK TV channel||Online stream|
|BT Sport Showcase / BT Sport 2||BT Sport app|
In the US, the match will be available to watch live on television on Fox Deportes and by stream via Fox Sports Go.
|US TV channel||Online stream|
|Fox Deportes||Fox Sports Go / Facebook Live|
SQUADS & TEAM NEWS
|Defenders||Lopez, Grimaldo, Luisao, Douglas, Eliseu, Dias|
|Midfielders||Fejsa, Augusto, Samaris, Zivkovic, Salvio, Pizzi, Cervi, Goncalves, Carvalho|
|Forwards||Jimenez, Jonas, Gabriel, Seferovic|
Benfica will be missing right-back Andre Almeida, who was sent off in the disastrous 5-0 defeat against Basel, as well as Jardel and Rafa Silva.
Barcelona loanee Douglas is likely to deputise in the absence of Almeida.
Potential starting XI: Svilar; Douglas, Luisao, Dias, Grimaldo; Zivkovic, Pizzi, Fejsa, Cervi; Jonas, Jimenez.
|Position||Man Utd players|
|Goalkeepers||De Gea, Romero, Pereira|
|Defenders||Blind, Lindelof, Valencia, Shaw, Smalling, Darmian, Tuanzebe, Jones, Rojo|
|Midfielders||Young, Lingard, Matic, Mkhitaryan, Mata, Herrera, McTominay|
|Forwards||Rashford, Lukaku, Martial|
Luke Shaw and Marcos Rojo have travelled to Portugal but would be surprise starters given their lack of match fitness after serious injuries.
Jose Mourinho will continue to be stretched in midfield due to the absences of Paul Pogba, Michael Carrick and Marouane Fellaini, while Eric Bailly and Zlatan Ibrahimovic are also out.
Potential starting XI: De Gea; Valencia, Smalling, Jones, Blind; Herrera, Matic; Mata, Mkhitaryan, Rashford; Lukaku.
BETTING & MATCH ODDS
Man Utd are 5/6 favourites to win, according to dabblebet, with Benfica priced at 7/2 and the draw available at 5/2.
When Jose Mourinho starts stirring up trouble, there's usually something else going on he doesn't want to talk about.
Things seem pretty good for the Red Devils right now, though, which made the talk around a potential new contract and his public admiration of Paris Saint-Germain somewhat puzzling.
Mourinho was hardly isolated in his belief that a more cautious approach against Liverpool was appropriate, and that debate was blowing over anyway.
Perhaps the Portuguese is anticipating more difficult winds to come while Paul Pogba and Marouane Fellaini remain absent, though Benfica's 5-0 humbling at Basel last time out and away matches at Huddersfield Town and Swansea City hardly suggest a severe challenge.
The Portuguese is not taking his compatriots lightly, though, claiming bluntly that they are "much better than CSKA Moscow and Basel".
We might not expect United to dazzle on this particular European trip and instead keep a clean sheet at the forefront of their minds as a result.