The side from Madrid came from behind to win 2-1 when they met back in September in what remains Barca's only away league defeat so far.
Barca remain extremely tough to beat in front of their own fans, where they have only lost one of their last 46 La Liga games.
bet365 offer them at 1/8 (1.12) with Leganes available at 20/1 (21.00), a price which reflects their away record of just one win in their previous 25 away matches. The draw can be backed at 8/1 (9.00).
Watch and bet on Barcelona vs Leganes
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Barca are still missing Samuel Umititi and Rafinha who are long-term absentees, with Thomas Vermaelen continuing to be sidelines. Marc-Andre Ter Stegen was rested midweek in the Copa del Rey but will return in goal.
Lega are without forwards Michael Santos and Diego Rolan, while defender Ezequiel Munoz is also missing.
No team has scored fewer goals than Leganes in La Liga this season.
Los Pepineros head to the Camp Nou to face a Barca side who have notched more than three times as many strikes as them.
Indeed, Mauricio Pellegrino's men have failed to score in six of their last eight La Liga games away from the Estadio Butarque and there is a temptation to back them to draw another blank on Sunday evening.
Tips and predictions
Barcelona are offered at 8/11 (1.72) to win to nil and this bet has paid out in each of their last three home matches.
Leganes have struggled in the final third this season and in the toughest away game of the campaign, there is every chance they will fail to score.
Odds correct at time of writing. Please gamble responsibly.