Los Che have the second leg of their Copa semi final on Thursday and having only lost 1-0 at the Camp Nou in the first match, that might condition how they approach their visit to the capital.
Watch and bet live on Atletico Madrid v Valencia
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For the game against Barca on Thursday night, Valencia were without several first choice players as Goncalo Guedes, Geoffrey Kondogbia, Jeison Murillo and Ezequiel Garay all missed out.
Filipe Luis is Atleti's only doubt for the game.
Hosts to continue dominant home form
Atletico have had an entire week to prepare this clash and will feel confident about claiming a win against a side on just two days of rest.
Their last home match saw a stunning individual performance from Antoine Griezmann and if the Frenchman turns on the style once more, Valencia could be in trouble.
The visitors have injuries, are out of form and face a Copa del Rey semi final four days after their visit to the Wanda Metropolitano, so should certainly be opposed.
Tips and predictions
The hosts to win and under 3.5 goals in the game is priced at 6/5 (2.20) and looks a solid option, with this bet having paid out in all six of Los Rojiblancos' home league wins this term.