Ernesto Valverde's side dropped points at home last weekend against Valencia and they will be hoping to avoid another slip-up when they visit the Basque Country.
Athletic, meanwhile, sit just three points above the relegation places and need a win to put some more distance between themselves and the drop zone.
Athletic are unbeaten at home in La Liga since October 5 - a run of six matches - and bet365 price them at 5/1 (6.00) for a win. Barca are 4/6 (1.66) to record their eighth away win of the season and the draw is offered 3/1 (4.00).
Watch and bet live on Athletic Club vs Barcelona
bet365 customers in the UK can watch and bet live on this fixture. Your account must be funded or active (have placed a bet in the last 24 hours) to enjoy the action.
Lionel Messi started the midweek Copa del Rey Clasico on the bench. The Argentine only came on for the last half an hour and it remains to be seen whether he has fully recovered from the knock he picked up last weekend.
Ousmane Dembele has missed the last few games with an ankle injury but looks like being ready to return. Samuel Umtiti and Rafinha remain sidelined.
Athletic remain without Aritz Aduriz - their only recognised centre-forward.
The division's biggest sides always view a trip to San Mames as one of the toughest away games of the season.
Athletic are likely to make Barcelona have to fight hard, and despite not being at their best this season, the Basques' home record remains strong.
Indeed, they held Barca to a 1-1 draw at Camp Nou this season, and last term made them work hard for a 2-0 away win at San Mames.
Prior to that, Barca's previous three wins in Bilbao had all come by single goal margins, while 2017 saw Athletic beat them 2-1 at home in the Copa del Rey.
Tips and predictions
Under 2.5 goals in the game is priced at 6/5 (2.20) and has paid out in the last three meetings between these two sides. Opposing an early goal could also be a solid option with no goal before 26 minutes offered at 5/6 (1.83).
Odds correct at the time of writing. Please gamble responsibly.