The Gunners are red-hot favourites to come out on top. 888Sport offer just 4/11 (1.36) about a home win, which would be their seventh consecutive Premier League over the Magpies.
Rafael Benitez's men have garnered 14 points from their previous eight matches but they're 8/1 (9.0) shots to win here, having lost 11 of their previous 12 meetings with Arsenal. A draw is available at 19/5 (4.80) with the same firm.
Danny Welbeck and Rob Holding remain sidelined for the home side who went to Dubai for a training camp during the international break.
Granit Xhaka's participation is in question while Aaron Ramsey withdrew from the Wales squad. His thigh problem isn't thought to be serious enough to completely rule him out of this game though.
Scott Langstaff and Rob Elliot are long term absentees for the visitors while captain Jamaal Lascelles missed the 2-2 draw with Bournemouth last time out.
Arsenal have won all six of their home league matches this calendar year but Newcastle's recent upturn makes the 4/11 (1.36) on a Gunners win look too short.
Despite only scoring 31 top-flight goals this term, 12 of those have come in the visitors' last eight matches. The arrival of record signing Miguel Almiron appears to have added some much-needed creativity to the Magpies' attack.
The reverse fixture ended 2-1 to Unai Emery's men and this clash could see a similar outcome.
Predictions and Tips
Both teams to score is 10/13 (1.77) with 888Sport and looks the best bet. Arsenal have conceded in 10 of their 16 Premier League games at the Emirates this season and the visitors should find some joy in the final third based on their recent performances.
A home win where both teams find the net is 37/20 (2.85) and having landed in the last meeting between the pair at St. James' Park it could be a solid option for those seeking a bigger price.