The Gunners have bounced back from a run of four consecutive defeats by winning five matches in a row in all competitions.
Having gone 22 league home games against this opposition without tasting defeat, they are 8/15 (1.53) favourites with bet365 to continue their resurgence by coming out on top once again here.
Meanwhile, Mark Hughes saw his side thrashed 3-0 by fellow relegation battlers West Ham in his first league match in charge, but can be backed at 5/1 (6.00) to mastermind a morale-boosting win in this one.
The sides shared a 1-1 draw when they met at St Mary’s in December’s reverse fixture, and you can get odds of 10/3 (4.33) on them cancelling each other out once again.
Petr Cech and Danny Welbeck are back in full training after injuries, leaving long-term absentee Santi Cazorla as the only player missing from Arsene Wenger’s squad.
Steven Davis is fit again and could return to the Saints team, while Oriol Romeu and Maya Yoshida will also be pushing for a start.
Hughes will certainly be looking to make changes after seeing his new side put in an dour performance at the London Stadium.
Indeed, the Saints conceded three goals against a relegation rival for the second successive league game after a 3-0 reverse at Newcastle United.
If those relatively blunt forward lines can cause that many problems, an Arsenal side that has scored at least three times in each of their last four home games should have little trouble in racking up the goals.
With the hosts having only conceded twice in those four fixtures, odds of 11/8 (2.38) are well worth backing on an uninspired Southampton losing by at least two goals for their third league game in a row.