The 27-year-old, who spent last season on loan with French outfit Nantes, is one of five players cut from 28 players currently in camp in the United Arab Emirates.
USA-based midfielder Ebenezer Ofori, who played at the 2017 Afcon, Ghana U-23 captain Yaw Yeboah and the local-based duo of Mohammed Alhassan (Hearts of Oak) and Abdul Safiu Fatawu (Asante Kotoko) complete the quintet.
Although coach James Kwesi Appiah named a 29-man provisional roster, the team was reduced to 28 men on Thursday following an injury to St. Gallen centre-back Musah Nuhu, who consequently returned to his Swiss club.
The squad has been named a day after Ghana succumbed to a shocking 1-0 loss to Namibia in a pre-tournament friendly on Sunday.
At the Afcon finals, the Black Stars, who will be seeking to win their fifth continental title and their first since 1982, have been drawn against cup holders Cameroon, Benin and Guinea-Bissau in Group F.
Andy Yiadom (Reading, England), Abdul Rahman Baba (Reims, France), Lumor Agbenyenu (Goztepe, Turkey), Kasim Nuhu Adams (Hoffenheim, Germany,) John Boye (Metz, France), Jonathan Mensah (Columbus Crew SC, USA), Joseph Aidoo (Genk, Belguim), Joseph Attamah (Istanbul Basaksehir, Turkey)
Mubarak Wakaso (Deportivo Alaves, Spain), Thomas Teye Partey (Atletico Madrid, Spain), Kwadwo Asamoah (Internazionale, Italy), Afriyie Acquah (Empoli, Italy), Andre Ayew (Fenerbahce, Turkey), Christian Atsu (Newcastle United, England), Samuel Owusu (Cukaricki, Serbia), Thomas Agyepong (Hibernian, Scotland)