Ghana eventually failed to pick a home win in the 2018 Fifa World Cup qualifiers as they shared the spoils 1-1 with Egypt at the Cape Coast Sports Stadium on Sunday.
Shikabala's opener in the second half was cancelled out by Edwin Gyasi, whose effort took a slight deflection.
Ghana coach Kwesi Appiah paraded a youthful side as part of his project to build a formidable side ahead of the 2019 Africa Cup of Nations.
Goalkeeper Richard Ofori maintained his place in the post, with Harrison Afful starting ahead of Daniel Opare in the right side of defence. Lumor Agbenyenu was on the left, with Kassim Nuhu and Daniel Amartey completing the back half.
Mubarak Wakaso, Edwin Gyasi, Ebenezer Ofori and Godfred Donsah made up the midfield while Raphael Dwamena and Nana Ampomah spearheaded the attack.
Egypt were without Liverpool star Mohammed Salah but his absence was hardly felt, as the Pharaohs threatened the hosts in the opening minutes.
Shikabala's pass on third minute failed to find Ramadan Sobhi while Mahmoud Ibrahim Trezeguet shot wide six minutes later.
On 22nd minute, Ghana had their first goal opportunity after Donsah set up Dwamena, who kept his cool and went past his marker but wasted his final effort.
Nana Ampomah's debut game for Ghana ended sadly. He collided with an opponent and was stretchered off by the 40th minute. The 21-year-old failed to recover and was replaced by Patrick Kojo Twumasi.
Sobhi almost scored the opener by the 43rd minute after he went past Wakaso and set up Trezeguet but the latter's last ditched effort was pushed to corner by goalkeeper Ofori.
A minute later, the home supporters thought they were about to celebrate the first goal but Egypt goalkeeper Ekramy thwarted the effort.
Ebenezer Ofori played Dwamena through on goal and the Swiss-based striker almost rounded the visitors’ goalkeeper but the latter pushed the ball for a corner-kick.
Wakaso could have handed Ghana the lead before the break, but once more his effort failed to find the target.
The Black Stars returned from the break stronger but the North Africans soon took charge by the 53rd minute.
Shikabala found a breach in Ghana's defence and scored the opening goal for the visitors by the 61st minute.
However, Gyasi pulled even three minutes later. The Netherlands-based striker saw his shot take a slight deflection off Ali Gabr to beat Egypt goalkeeper.
Appiah brought on Richmond Boakye Yiadom for Dwamena on 74th minute and altered his formation. That change almost paid off but the visitors defence was on alert to block a shot from the Red Star Belgrade striker.
With eight minutes remaining, Ghana pushed men forward in a bid to claim a first home win in the qualifying, but Twumasi, Gyasi and Waris fluffed the opportunities that came their way.
Ghana finished third in Group E with seven points, six points behind Egypt with Uganda occupying second position.