Mauricio Pochettino's side are currently fifth in the Premier League on 49 points, four points ahead of their bitter foes, and a win could see them move up to third.
Defeat for Arsene Wenger's Gunners would be a major blow to their hopes of achieving a top-four finish, so they will be desperate to claim maximum points.
|Game||Tottenham vs Arsenal|
|Date||Saturday, 10 February|
|Time||12:30 GMT / 07:30 ET|
|Stream (US only)||fubo TV (7-day free trial)|
TV Channel & Live Stream
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|CNBC / NBC Universo||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on TV on BT Sport 1 and it can be streamed live online using the BT Sport app.
|UK TV channel||Online stream|
|BT Sport 1||BT Sport app|
Squads & Team News
|Goalkeepers||Lloris, Vorm, Gazzaniga|
|Defenders||Trippier, Rose, Alderweireld, Vertonghen, Sanchez, Foyth, Aurier, Davies, Walker-Peters|
|Midfielders||Lamela, Wanyama, Dier, Sissoko, Dembele, Alli, Eriksen, Lucas, Winks, Georgiou, Oakley-Boothe|
|Forwards||Son, Kane, Llorente, Sterling|
Spurs are boosted by the return to full fitness of Toby Alderweireld, while Danny Rose and Harry Winks are also available again. New signing Lucas Moura could make his Premier League debut, but it is likely to be from the bench as Pochettino is unlikely to experiment in such a massive game.
Potential Tottenham starting XI: Lloris; Trippier, Sanchez, Vertonghen, Davies; Dier, Dembele, Eriksen, Son, Alli; Kane.
|Goalkeepers||Cech, Ospina, Macey|
|Defenders||Mertesacker, Koscielny, Holding, Monreal, Mustafi, Chambers, Bellerin, Mavropanos, Kolasinac, Osei-Tutu|
|Midfielders||Mkhitaryan, Ramsey, Wilshere, Ozil, Iwobi, Cazorla, Xhaka, Maitland-Niles, Elneny, Dragomir, Willock, Gilmour|
|Forwards||Lacazette, Aubameyang, Welbeck, Dasilva, Nelson, Nketiah|
Arsenal will be without Petr Cech, who has not been training, meaning that David Ospina will start between the posts. Danny Welbeck is a concern, but Wenger hinted that the striker will be back for the game. Nacho Monreal, meanwhile, is poised to return to the team.
Potential Arsenal starting XI: Ospina; Monreal, Mustafi, Koscielny; Bellerin, Kolasinac, Xhaka, Ozil, Ramsey, Mkhitaryan; Aubameyang.
Betting & Match Odds
Despite losing when they last played, Tottenham are deemed to be favourites at 19/20 according to dabblebet. Arsenal are priced at 11/4 and a draw is a 14/5 bet.
Arsenal defeated Spurs when the sides met at the Emirates Stadium back in November but they come into the game at Wembley as slight underdogs due to their hosts' impressive recent form.
Pochettino's side are unbeaten in their last 11 games - seven of which were wins - and they claimed a morale-boosting victory over Manchester United just over a week ago.
The Gunners, on the other hand, have been incredibly inconsistent, picking up four wins in their last 10 games, losing three, and their hopes of securing Champions League football are fading.
Defeats to Swansea, Bournemouth, Watford and Stoke City also blot their record in this campaign, but Wenger will hope that the January additions of Henrikh Mkhitaryan and Pierre-Emerick Aubameyang will be enough to inspire his side in the remaining games.