In the wake of World Cup exit, Ozil felt he was made a scapegoat and chose to quit the international game, citing racism as one of the reasons why he was taking a step back.
It is a stance that has provoked a great deal of debate in his homeland, and Low has been left upset by the actions of the 29-year-old.
“I expected him to call me, that he would call me personally and tell me,” the national team coach told ZDF after a scoreless draw with France in the Nations League on Thursday. “So that’s why I’m disappointed. I’m disappointed with him on human terms. We’ve been together for many years.”
Although the coach seemed to suggest that there was no prospect of the former Real Madrid man being welcomed back into the international fold, he did hint the door might still be open.
“I’ll take the initiative again,” Low said.
Meanwhile, defender Mats Hummels has admitted that he did not expect a picture of Ozil posing with controversial Turkish President Recep Tayyip Erdogan to cause such an issue – the incident that acted as a catalyst to all that would follow.
“We talked about it internally, but I didn’t think it would be as influential on our performance as it probably was in the end,” he admitted to Kicker. "Maybe that was wrong."
Ilkay Gundogan, who was also at that meeting with Erdogan before the World Cup, was given something of a mixed reception when he came on as a substitute in Thursday's match in Munich.
The Manchester City man admits he felt anxious before his introduction but was pleased to see many of the fans applaud him onto the pitch.
"I was nervous when I started getting ready on the bench," he said. "I don't have to be scared, but there was a bit of nervousness, because I didn't know how much of a reaction there would be.
"I was very happy there was so much applause, so I applauded back. From then on, I could concentrate fully on the game."
Germany turned in an encouraging performance against the world champions on Thursday, forcing a number of excellent saves from debutant France keeper Alphonse Areola. However, they were unable to make a breakthrough and go into their friendly with Peru on Sunday seeking just a third win in eight internationals.
Ozil, of course, will not be present in their ranks, having won 92 caps for his country, scoring 23 goals. Furthermore, he was a key member of the squad that won the 2014 World Cup in Brazil.
Instead, he remains with Arsenal, where coach Unai Emery has been forced to field questions over his relationship with the player, who has been accused of not trying hard enough.