The Red Devils were soundly beaten by Mauricio Pochettino's side at Wembley on Wednesday, picking up their fourth league defeat of the season in a 2-0 turnover.
In Huddersfield, they come up against another side who has punished them this season, the Terriers having won 2-1 in the corresponding fixture back in October.
While revenge and a desire to bounce back will be on their mind, it will also be a solemn occasion for the club as they commemorate the 60th anniversary of the Munich air disaster.
|Game||Manchester United vs Huddersfield Town|
|Date||Saturday, February 3|
|Time||15:00 GMT / 10:00 ET|
|Stream (US only)||fuboTV (7-day free trial)|
TV CHANNEL & LIVE STREAM
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
In the United Kingdom (UK), the game cannot be watched live on TV due to the fact that it falls within the blackout period, but it can be followed live with Goal here.
|UK TV channel||Online stream|
SQUADS & TEAM NEWS
|Position||Man Utd players|
|Goalkeepers||De Gea, Romero, Joel Castro|
|Defenders||Lindelof, Jones, Rojo, Smalling, Shaw, Valencia, Darmian|
|Midfielders||Pogba, Mata, Lingard, Carrick, Young, Herrera, Fellaini, Matic, McTominay, Gomes|
|Forwards||Sanchez, Lukaku, Martial, Rashford|
Eric Bailly and Zlatan Ibrahimovic are both unavailable as they continue to recover from groin and knee issues, respectively.
Marouane Fellaini will miss out after suffering a knee injury in the mid-week match against Spurs, while Daley Blind could be in line for a return.
Potential Man Utd starting XI: De Gea; Valencia, Jones, Smalling, Young; Pogba, Matic, Lingard; Martial, Sanchez, Lukaku
|Goalkeepers||Lossl, Coleman, Green|
|Defenders||Smith, Malone, Kongolo, Lowe, Jorgensen, Schindler, Hadergjonaj, Hefele|
|Midfielders||Whitehead, Hogg, Scannell, Billing, Mooy, Sabiri, Van La Parra, Pritchard, Ince, O'Brien|
|Forwards||Depoitre, Quaner, Mounie|
Huddersfield will be without a number of players for the game, with Danny Williams among those expected to miss out.
The Terrier will also have to make do without two long-term absentees in the form of Jon Stankovic and Elias Kachunga.
Potential Huddersfield Town starting XI: Lossl; Kongolo, Schindler, Jorgensen, Lowe, Hadergjonaj; Hogg, Billing, Mooy; Depoitre, Mounie.
BETTING & MATCH ODDS
Manchester United are heavy favourites according to dabblebet, who price the Red Devils at 1/6 to win. Huddersfield are rated 18/1 bets, while a draw is available at 13/2.
Jose Mourinho is hopeful that his players will rise to the occasion against Huddersfield on Saturday as Manchester United honour those who lost their lives in the Munich air disaster.
The club is getting ready to mark the 60th anniversary of the tragedy and there will be a minute's silence ahead of the game against the Terriers.
"I think it should affect [the players] in a positive way," Mourinho told MUTV.
"If we believe they are watching the match I think it's one more reason for a happy day and for a good performance and a manifestation of United colours.
"So yes, of course a minute of silence for them and for the families, but I think they would love happiness, joy, a Manchester United victory, points, goals... I think they would love that."
A Man United victory may not be so straightforward, however, considering Huddersfield upset the Red Devils already this season.
Nevertheless, there will be a heightened appetite for glory, particularly in light of their capitulation against Spurs earlier in the week.