Jurgen Klopp's side are just two points behind the Red Devils, who are not in action until Monday evening, and they come into the game on the back of a three-game winning streak.
Newcastle, meanwhile, are in the bottom half of the table, but Rafa Benitez's side have started to pick up points in recent weeks, including a win over Man United.
The two teams could not be separated when they met at St James' Park earlier in the season so a tight affair is to be expected.
|Game||Liverpool vs Newcastle United|
|Date||Saturday March 3|
|Time||17:30 GMT / 12:30 ET|
|Stream (US only)||fubo TV (7-day free trial)|
TV Channel & Live Stream
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|NBC Universo||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on TV on BT Sport 1 and it can also be streamed live online using the BT Sport app.
|UK TV channel||Online stream|
|BT Sport 1||BT Sport app|
Squads & Team News
|Goalkeepers||Karius, Mignolet, Ward|
|Defenders||Clyne, Van Dijk, Lovren, Gomez, Klavan, Moreno, Robertson, Matip, Alexander-Arnold|
|Midfielders||Wijnaldum, Henderson, Milner, Lallana, Oxlade-Chamberlain, Can, Woodburn, Paulinho|
|Forwards||Firmino, Salah, Mane, Ings, Solanke, Brewster|
Liverpool have a number of injury concerns heading into the game with James Milner, Georginio WIjnaldum and Ben Woodburn all considered doubts.
Jordan Henderson and Danny Ings should be fit enough to be involved but Nathaniel Clyne is expected to be given more time to regain full fitness.
Potential Liverpool starting XI: Karius; Alexander-Arnold, Lovren, Van Dijk, Robertson; Henderson, Can, Oxlade-Chamberlain; Mane, Salah, Firmino.
|Goalkeepers||Elliot, Dubravka, Darlow|
|Defenders||Clark, Dummett, Lascelles, Mbemba, Manquillo, Lejeune, Yedlin, Haidara, Gamez|
|Midfielders||Murphy, Shelvey, Diame, Ritchie, Hayden, Kenedy, Merino, Atsu|
|Forwards||Gayle, Slimani, Perez, Joselu|
Former Reds midfielder Jonjo Shelvey will not be available to face his old club, while on-loan striker Islam Slimani is also expected to miss out.
However, in a boost, Matt Ritchie and Dwight Gayle are likely to be involved.
Potential Newcastle starting XI: Dubravka; Lejeune, Lascelles, Yedlin, Dummett; Atsu, Ritchie, Kenedy, Diame; Perez, Gayle.
Betting & Match Odds
At 1/5, Liverpool are favourites to win according to dabblebet, with Newcastle priced at 12/1. A draw is considered a 6/1 bet,
When Liverpool met Newcastle at St James' Park back in October, Philippe Coutinho was their star man and got their goal in what finished a 1-1 draw. The result saw them drop to seventh.
A lot has changed since then. Coutinho left for Barcelona in a €160 million move and, as the Reds fight to ensure that they finish second in the table, Klopp believes they are a better team.
"I'm really happy with the reaction from the boys, they've stepped up," the German coach said. "We wanted to keep Phil, he decided differently and I am happy that it has worked quite well so far."
Indeed, the form of Mohamed Salah in particular has been a massive positive for Liverpool and he has been ably supported by Roberto Firmino and Sadio Mane.
As he prepares to return to his former stomping ground, Newcastle boss Benitez is aware of the magnitude of the task that awaits his side.
"It's not just him (Salah), Roberto Firmino, Sadio Mane, anyone can be a threat," said the Spanish coach.
"They have pace, energy, not just him. We have to try to control everyone with concentration and intensity."