Liverpool are looking to extend their unbeaten home run on Saturday evening, with Rafa Benitez's Newcastle the visitors.
The Reds are still unbeaten at Anfield in the Premier League this season (14 games), their longest unbeaten home stretch since 2008-09.
Newcastle are just two points from safety after 28 fixtures and will be determined to separate themselves from the bottom three with a victory.
Here, Goal takes a look at everything you need to know ahead of the game.
Nathaniel Clyne has continued his comeback from injury by playing for the Under-23s, though remains unavailable for first-team selection.
Georginio Wijnaldum and Danny Ings were both ruled out for the Reds' last outing against West Ham but are both recovering from illness and could play a part on Saturday.
Emre Can is likely to continue in central midfield, though Jordan Henderson is back in contention.
Liverpool do not have any suspended players ahead of the tie.
Liverpool potential starting line-up
Jurgen Klopp could start with the XI which beat West Ham 4-1 last weekend, with Mohamed Salah, Roberto Firmino and Sadio Mane all finding the net once again.
Alex Oxlade-Chamberlain has started the last two Premier League games and impressed enough to warrant a starting spot once more, though Jordan Henderson's return may see him drop to the bench.
Newcastle team news
Jonjo Shelvey will play no part against his former club due to a knee injury, while Islam Slimani is sidelined with a thigh strain.
Striker Dwight Gayle faces a late fitness test before the game, and Jesus Gamez has failed to recover from an ankle injury.
TV channel & kick-off time
The fixture will be broadcast live in the UK (United Kingdom) on BT SPORT 1 or BT SPORT 4K UHD from 17:00 GMT.
In the United States, the game can be watched live on television on NBC Sports and kicks off at 12:00 ET.
Best Opta match facts
- Liverpool are unbeaten in 21 home league games against Newcastle (W17 D4 L0), since a 0-2 loss in April 1994 thanks to goals from Rob Lee and Andy Cole.
- Liverpool have scored more Premier League goals against Newcastle than they have vs any other side in the competition (89).
- All three of Rafael Benitez’s Premier League games against his former side Liverpool have finished as draws, with both at Anfield finishing 2-2.
- Roberto Firmino has both scored and assisted in six different Premier League games this season – more than any other player.
- Mohamed Salah has scored in each of his last six games for Liverpool in all competitions – the last player to do so in more was Daniel Sturridge in February 2014 (8).