Jurgen Klopp has opted for his most potent attacking combination against Arsenal, with Mohamed Salah, Sadio Mane, Philippe Coutinho and Roberto Firmino all starting.
The Senegal international returns to the XI having been rested in the 4-0 victory over Bournemouth on Sunday, with Alex Oxlade-Chamberlain — back at his former club for the first time since his £35 million summer switch — held in reserve.
Emre Can joins Jordan Henderson in midfield having served a one-match ban for the totting up of yellow cards in the only other change to the 11.
Coutinho, meanwhile, marks his 150th league game for Liverpool.
Liverpool starting XI: Mignolet, Gomez, Lovren, Klavan, Robertson, Henderson, Can, Coutinho, Mane, Salah, Firmino
Liverpool subs: Karius, Alexander-Arnold, Milner, Wijnaldum, Lallana, Oxlade-Chamberlain, Solanke