The Bianconeri are ahead of the Maurizio Sarri's side by two points with nine games remaining and host their challengers at the Allianz Stadium on April 22, having won the reverse fixture 1-0 in December.
Crespo, who spent much of his career in Serie A playing for a number of clubs, including Parma, Lazio and Inter, feels that the league leaders' previous title-winning experience will stand them in good stead as they look to win a seventh consecutive championship.
"For the title race I think Juventus have a double advantage," the 42-year-old told Omnisport, speaking courtesy of Hublot.
"They have more points and they know how to win the Scudetto.
"Napoli lack a bit of experience but they are having an amazing championship. It would be nice for Italian football if Napoli could win.
"I think that Juventus-Napoli could be decisive."