Arsenal will face Irish champions Dundalk, Rapid Vienna, Molde in the group stage of the 2020-21 Europa League, while Tottenham take on Ludogorets, LASK and Royal Antwerp.
Elsewhere, Leicester will face Braga, AEK Athens and Zorya Luhansk, while Scottish title holders Celtic have been placed alongside Serie A giants AC Milan.
Neil Lennon’s side, who failed to qualify for the Champions League, also face tough tests against Lille and Sparta Prague.
Their Old Firm rivals Rangers, who continue to work under the guidance of Liverpool legend Steven Gerrard, have fixtures lined up against Portuguese heavyweights Benfica, Standard Liege and Lech Poznan.
Roma will hope that they have enough to overcome Young Boys, Cluj and CSKA Sofia, while their domestic foes Napoli must take on Real Sociedad, AZ Alkmaar and Rijeka.
Bayer Leverkusen and Nice have been placed in the same group and PSV have meetings with Granada to come in their section of the draw.
All of the teams in the running for a prestigious prize will be looking to make their way to the final in Gdansk on May 26, 2021.
It remains to be seen whether any of those who reached the latter stages of the competition last season will come back into contention for the crown 12 months on.
All four of the semi-finalists from 2019-20 – Sevilla, Inter, Manchester United and Shakhtar Donetsk - will be competing in the group stage of the Champions League.
Sevilla landed the trophy last time out, for a sixth time in their history, but will be hoping to avoid being put in a position to defend that prize.
Plenty of others will fancy their chances of staking a serious claim for a famous piece of silverware, with Premier League hopefuls among them.
Arsenal reached the final back in 2019, when they lost to London neighbours Chelsea, while current Spurs boss Jose Mourinho guided Manchester United to Europa League glory in 2017.
2020-21 Europa League group stage draw in full:
Group A: Roma, Young Boys, Cluj, CSKA Sofia
Group B: Arsenal, Rapid Vienna, Molde, Dundalk
Group C: Bayer Leverkusen, Slavia Prague, Hapoel Beer-Sheva, Nice
Group D: Benfica, Standard Liege, Rangers, Lech Poznan
Group E: PSV, PAOK, Granada, Omonia
Group F: Napoli, Real Sociedad, AZ Alkmaar, Rijeka
Group G: Braga, Leicester, AEK Athens, Zorya Luhansk
Group H: Celtic, Sparta Prague, AC Milan, Lille
Group I: Villarreal, Qarabag, Maccabi Tel Aviv, Sivasspor
Group J: Tottenham, Ludogorets, LASK, Royal Antwerp
Group K: CSKA Moscow, Dinamo Zagreb, Feyenoord, Wolfsberg
Group L: Gent, Red Star Belgrade, Hoffenheim, Liberec