However, Celta can take solace from United's dismal record of two wins in 22 previous visits to Spain as the sides contest a place in the final in Stockholm at the end of this month.
"Rather than feared, I would say United are respected," Berizzo told a pre-match news conference. "We have played against great teams in this Europa League, but Man United are definitely one of the greatest.
"How do we win? By being faithful to who we are. The team has a clear identity, they believe in it - possession, attacking quickly - and the only way to beat United is to be faithful to who we are.
"United change according to the rival they play against and we have to be ready for that, but we will win with identity, conviction and heart and hope that United's statistic stays as it is - two wins in Spain."
Former Manchester City youngster John Guidetti is expected to lead the attack alongside Iago Aspas, who is again enjoying himself at Celta having put wretched spells at Liverpool and Sevilla behind him.
"Iago has experienced personal maturity and that is the difference, which is more than my influence on him," Berizzo added.
"He has really assumed leadership of the team and playing on the right really liberates him.
"That enables him to combine better with the central forwards and become an important player for us."