The Russian side recorded an impressive 2-1 win at Benfica on matchday one.
|Game||CSKA Moscow vs Manchester United|
|Date||Wednesday, September 27|
|Time||19:45 BST / 14:45 ET|
TV CHANNEL & LIVE STREAM
In the UK, the game will be available to watch live on television on BT Sport 3 and by stream via the BT Sport app.
|UK TV channel||Online stream|
|BT Sport 3||BT Sport app|
In the US, the game will be available to watch live on television on FS1 and by stream via Fox Sports Go.
|US TV channel||Online stream|
|FS1||Fox Sports Go|
SQUADS & TEAM NEWS
|Position||CSKA Moscow players|
|Goalkeepers||Pomazun, Akinfeev, Kyrnats|
|Defenders||Ignashevich, Vasin, A. Berezutski, Nababkin, V. Berezutski, Schennikov|
|Midfielders||Wernbloom, Milanov, Dzagoev, Golovin, Makarov, Natcho, Gordyushenko, Khosonov, Kuchaev|
|Forwards||Vitinho, Chalov, Zhamaletdinov, Olanare|
CSKA look set to be without wing-back Mario Fernandes, who suffered a concussion against Dinamo Moscow at the weekend.
Kirill Nababkin came off the bench to replace him and is likely to start in his absence.
Potential starting XI: Akinfeev; Ignashevich, V. Berezutski, A. Berezutski; Nababkin, Dzagoev, Wernbloom, Golovin, Schennikov; Vitinho, Zhamaletdinov.
|Position||Man Utd players|
|Goalkeepers||De Gea, Romero, Pereira|
|Defenders||Bailly, Smalling, Blind, Lindelof, Tuanzebe, Darmian|
|Midfielders||Herrera, Matic, McTominay, Lingard, Young, Mkhitaryan, Mata|
|Forwards||Lukaku, Martial, Rashford|
Jose Mourinho will have limited options in midfield, with Paul Pogba, Michael Carrick and Marouane Fellaini all out. Phil Jones will also be unavailable due to an unspecified problem.
Marcos Rojo and Zlatan Ibrahimovic are long-term absentees and Antonio Valencia and Luke Shaw have not travelled. The former is being given a rest and the latter is working his way back from injury.
Potential starting XI: De Gea; Darmian, Bailly, Smalling, Blind; Herrera, Matic; Mata, Mkhitaryan, Martial; Lukaku.
BETTING & MATCH ODDS
Man Utd are 4/6 favourites to win, according to dabblebet, with CSKA priced at 17/4 and the draw available at 11/4.
This may not read on paper as a major test of Manchester United's credentials at the top level but it may well turn out to be their toughest match of the season.
Jose Mourinho has described this CSKA Moscow side as the best Russian club he has faced during his management career, led as they are in midfield by the accomplished Alan Dzagoev and the promising Aleksandr Golovin.
United, on the other hand, will be missing Paul Pogba, Michael Carrick and Marouane Fellaini from their midfield group in Russia.
It is a big chance for Ander Herrera to prove to Mourinho that he deserves more minutes despite the excellent form of Pogba and his new partner Nemanja Matic.
Herrera should also get the chance to play with more freedom next to Matic, having last season mostly served in the more defensive role the Serbian now occupies.
If United can win the midfield battle, they have enough pace up front to trouble an ageing CSKA defence.