Coach Tite will kick off a new cycle for Brazil this week when his side meet USA with a first XI made up almost entirely of those who joined him at the World Cup.
One of the key changes, however, is in midfield where Manchester United man Fred will replace Paulinho.
The 25-year-old has his sights set firmly on World Cup 2022 and is now keen to establish himself as a regular first-team player for the five-time world champions.
"For us, it is a time to reform, to start all over again from scratch, looking to 2022,” said Fred, who on Friday is set to make his first Brazil start since June 2015.
“But we have these two friendlies, then we have Copa America, so there are a lot of things ahead of us. The first training session saw us begin to renew the team and the first game [against USA on Friday] will be very important to the process "
Fred was a member of the World Cup squad but an ankle injury kept him out of Brazil’s final warm-up match and he never made it onto the field in Russia.
But having also made it into the March squad, Fred is confident he will have no problem integrating into an established and consistent group.
"We have been playing together for some time, even though I have not played in the starting line-up,” he said.
“We train together and this is a group that has changed very little. There is a long-term relationship there.”