The 67-year-old's contract with Arsenal expires at the end of the season and the Frenchman has yet to reveal whether he'll be staying on as Gunners boss.
Inconsistent performances and dismal results throughout 2017 have prompted protests against Wenger signing a new deal but the man himself says that a loss at Wembley on Sunday wouldn't affect any potential decision.
"It doesn't play any part in that," he said. "The FA Cup is a very important game for me because it's the next game and because it's an opportunity to win a trophy this season. So, of course, we are all fully focused on that. My future is Sunday."
Wenger's decision to field three at the back for the first time in 20 years hinted that he is willing to change his ways and the explanation for the move was that he wanted to give Arsenal more defensive solidity - something that they will need in abundance against a potent attacking side this weekend.
"It was more designed to give us a bit more defensive solidity because recently away from home we conceded too many goals," Wenger said.
Danny Welbeck faces a fitness test before Sunday's game on a toe injury, while Shkodran Mustafi has been ruled out completely.
"Ospina is out and Lucas is still out," said Wenger. "They are longer-term injuries. Ospina could be back in 10 days."
French youngster Jeff Reine-Adelaide has been ruled out until the end of the season with an ankle injury, with Santi Cazorla another long-term absentee.
ARSENAL POTENTIAL STARTING LINE-UP
Wenger's decision to field three at the back caught everyone by surprise against Middlesbrough and he could choose to do the same again, although the likes of Leroy Sane and Raheem Sterling on the flanks could pose huge problems for the Arsenal defence.
"It's an option, yes. But what will I do? You will understand, I won't tell you now," Wenger told a news conference on Thursday.
Arsenal failings in big games exposed
Alexis is likely to start through the middle while Theo Walcott looks set to return following his omission against Boro, but a midfield partnership of Granit Xhaka and Aaron Ramsey is likely to be kept intact.
Mustafi's injury means that Rob Holding is likely to continue at centre-back next to skipper Laurent Koscielny.
MAN CITY DOSSIER
Gabriel Jesus looks set to return to the City squad following his recovery from a fractured metatarsal which has kept him out since February.
Former Arsenal defender Bacary Sagna is sidelined through injury, along with Germany international Ilkay Gundogan.
Sergio Aguero is their top scorer with 29 goals this season.
BEST OPTA MATCH FACTS
- This will be Arsenal’s 29th appearance in the FA Cup semi-finals – the most of any team in the competition’s history.
They’ve also won the trophy 12 times, a joint-record alongside Manchester United. Manchester City have progressed from each of their last eight FA Cup semi-finals, most recently in 2013 against Chelsea. Their last defeat at this stage was in 1932 against Arsenal.
Three of the last six meetings between these sides have finished 2-2, with Arsenal winning 2-1 and 2-0 and Man City winning 2-1 across the other three.
After losing their first two games at the new Wembley, the Gunners are unbeaten in their last six (W5 D1), including beating Wigan on penalties in the 2014 FA Cup semi-final.
Pep Guardiola won his only previous game in charge of a team at Wembley Stadium, beating Manchester United 3-1 with Barcelona in the 2011 Champions League final. He also played in the 1992 European Cup final there with Barca, beating Sampdoria 1-0.
Manchester City have had eight different goalscorers in the FA Cup this season, more than any other side left in the competition.
The Gunners come into this game on the back of just five wins in their last 13 games in all competitions (D1 L7), with two of those victories coming against non-league sides (Sutton Utd and Lincoln City).
TV COVERAGE & KICK-OFF TIME
Kick-off is at 15:00 BST on Sunday, 23 April and the match is live on BT Sport in the UK and on FOX Sports 1 in the US.