The 23-year-old joined the Gunners on loan from Real Madrid in the summer, with his early-season form for the north Londoners seeing him earn a recall to the national set-up.
Unai Nunez and Pablo Sarabia have also been included and could win their first international caps for their country.
Robert Moreno has made seven changes in all for the matches against Romania and Faroe Islands, his first since replacing Luis Enrique as head coach on a permanent basis in June.
The former Barcelona boss stepped down to care for his young daughter, who sadly died on Thursday following a battle with bone cancer.
His first major decisions are to give Athletic Bilbao defender Nunez and Paris Saint-Germain winger Sarabia the chance to impress.
Alvaro Morata, Marco Asensio, Inigo Martinez and Isco are all out through injury, while Iago Aspas, Santi Cazorla and Sergi Roberto have been dropped.
Spain have won four matches from four in qualifying to sit top of Group F, five points clear of second-placed Sweden.
Spain squad in full
Defenders: Jordi Alba (Barcelona), Dani Carvajal (Real Madrid), Jose Gaya (Valencia), Mario Hermoso (Atletico Madrid), Diego Llorente (Real Sociedad), Jesus Navas (Sevilla), Unai Nunez (Athletic Bilbao), Sergio Ramos (Real Madrid)
Midfielders: Sergio Busquets (Barcelona), Dani Ceballos (Real Madrid, on loan at Arsenal), Dani Parejo (Valencia), Rodri (Manchester City), Fabian Ruiz (Naples), Saul (Atletico Madrid), Suso (AC Milan), Thiago Alcantara (Bayern Munich)
Forwards: Paco Alcacer (Borussia Dortmund), Mikel Oyarzabal (Real Sociedad), Rodrigo (Valencia), Pablo Sarabia (Paris Saint-Germain)