The former Mathare United man has accumulated a total of five yellow cards meaning he is suspended for the trip down the coast.
Team manager Gilbert Selebwa feels the suspension is a blessing in disguise for the 12-time league champions.
"Definitely he will be missed, but again looking at it on a positive way, his absence brings an opportunity for others to show what they can do.
“We have the likes of Edward Seda who might be given a chance to show what he can do, we know he is talented.
"It will also provide Isuza with ample time to rest and be fresh for the upcoming matches, so it is a win-win situation."
The influential midfielder has scored nine goals for Leopards this season.