|Friday, May 20|
|7:00||Philadelphia Union||-||D.C. United||UniMas|
|Saturday, May 21|
|3:00||New York City FC||-||New York Red Bulls||Fox/TSN2|
|5:00||Chicago Fire||-||Houston Dynamo||MLS Live|
|5:00||Toronto FC||-||Columbus Crew||MLS Live|
|7:30||Orlando City||-||Montreal Impact||TSN5/MLS Live|
|7:30||New England Revolution||-||FC Dallas||MLS Live|
|8:30||Sporting Kansas City||-||Real Salt Lake||MLS Live|
|10:00||Seattle Sounders||-||Colorado Rapids||MLS Live|
|Sunday, May 22|
|4:30||Portland Timbers||-||Vancouver Whitecaps||ESPN|
|7:00||LA Galaxy||-||San Jose Earthquakes||FS1|
All times p.m. ET
Philadelphia Union vs. D.C. United: The I-95 rivals meet for the first time this season at Talen Energy Stadium. D.C. United started the season slow but put together one of its best performances of 2016 last week in a 2-0 win over the Red Bulls. Bill Hamid is still not ready to return from injury, so Travis Worra will get the nod in goal once again for the visitors. The Union will be looking for their first win in four matches after drawing their last three games.
New York City FC vs. New York Red Bulls: The season's first New York derby comes with NYCFC surprisingly in first place in the Eastern Conference, coming off three straight wins followed by a draw in Wednesday's match at Toronto FC. Patrick Vieira rested several starters in that midweek match, meaning he should have a full compliment of players in the Bronx Saturday. Frank Lampard could be set for his season debut after returning to full training this week. The Red Bulls, who won all three of last year's matches with their city rival, got back to winning ways with a 1-0 triumph over Chicago on Wednesday.
Chicago Fire vs. Houston Dynamo: It's last place in the Eastern Conference hosting last place in the Western Conference at Toyota Park on Saturday. The Fire in particular are reeling after losing four of their last five, including a 1-0 defeat at the Red Bulls on Wednesday. Houston has turned things around slightly after a rough start, winning two of its last three. Chicago has a league-worst eight goals scored and won't be able to feature new forward signing Michael de Leeuw until July.
Toronto FC vs. Columbus Crew: Jozy Altidore is out of action for Toronto and the Crew have their own set of striking issues with Kei Kamara having been shipped out recently. TFC currently has a five point lead on the Crew in the East, with Columbus holding a game in hand, and the Canadian outfit will be looking to open up an even larger advantage with a home win on Saturday.
Orlando City vs. Montreal Impact: It is certain the Impact, who are winless in five with draws in four straight, will be without Didier Drogba as he recovers from a hip flexor. Orlando City, winless in six with four draws over that span, will likely be without defender Seb Hines and need to rebound from a poor performance in a loss last week to Sporting KC.
New England Revolution vs. FC Dallas: The addition of Kei Kamara should be a boost to New England's attack, but even without a goal from the club's newest striker the Revs pulled out their second win of the season last week against Chicago. The Revs have a couple of key injury concerns with Teal Bunbury and Chris Tierney both still questionable with hamstring issues, while Dallas rolls into town without Matt Hedges and with Jesse Gonzalez and Max Urruti both listed as questionable.
Sporting Kansas City vs. Real Salt Lake: After a strong start to the season, things have gotten a little bumpier for Real Salt Lake, with three losses in their past four games. While all of those losses did come on the road, the team will be travelling again to face Sporting KC, though it did win 2-1 in Kansas City earlier this year. SKC snapped a seven-game winless streak with a 2-1 home win over Orlando City last week and have a chance to rack up some points with its next two contests in its friendly confines. RSL hopes Sunny can return after he made the bench but did not play in Houston last week.
Seattle Sounders vs. Colorado Rapids: These two teams met in Colorado on April 23, with the Rapids walking away 3-1 victors. Expect a different match this time around in Seattle as the Sounders, though winless in four road games, have won four of their six home matches thus far. The Rapids, who own the most points in MLS, are perfect at home this year but own just one win on the road in six attempts. Seattle looks fairly healthy for this encounter, while the Rapids are likely to be without Marco Pappa and Eric Miller once more.
Portland Timbers vs. Vancouver Whitecaps: The Timbers are losers of three straight and their poor run started with a 2-1 loss to the Whitecaps in Vancouver on May 7. Portland is also banged up as Diego Chara and Fanendo Adi appear to be questionable. Meanwhile that victory over the Timbers was the start of a three-game win streak the Whitecaps hope to extend Sunday. The Whitecaps will be without Fraser Aird due to suspension and Masato Kudo with injury.
LA Galaxy vs. San Jose Earthquakes: These two rivals met Mar. 13 with the Galaxy winning 3-1. That was the start of the Galaxy’s current eight-game unbeaten streak with four wins and four draws over that span. While the Earthquakes haven’t been as hot, they’ve been solid this season, with a 5-3-3 record. However the game will be at the StubHub Center, where LA has taken 13 of a possible 15 points this season, while the Earthquakes are winless on the road. The Earthquakes have plenty of injuries with Qunicy Amarikwa likely out, along with Clarence Goodson and Innocent, though Cordell Cato returned to action in a friendly Wednesday. The Galaxy are fairly healthy, with Alan Gordon currently the only question mark.