It is one of the great fixtures in the competition's history. In the final in 1999, United came from behind to snatch victory over Bayern with two goals in three minutes in added time. There was also the enthralling quarter-final tie in 2010, when Bayern came from behind in each leg to eventually progress at the Red Devils' expense.
Bayern are second in the Bundesliga and are unbeaten in their opening four matches, meaning they go into the match in far better shape than Erik ten Hag's side, who are 13th in the Premier League after losing three of their opening five matches. United also have a long list of injuries and will be without Aaron Wan-Bissaka as well as Raphael Varane and Mason Mount in addition to missing Antony and Jadon Sancho.
However, Bayern will be without manager Thomas Tuchel for Wednesday's game at the Allianz Arena.