Mauricio Pochettino's men can at least temporarily draw within one point of Antonio Conte's team, however, by taking three points at London Stadium.
|Game||West Ham vs Tottenham|
|Date||Friday, May 5, 2017|
|Time||20:00 GMT, 15:00 ET|
TV CHANNEL & LIVE STREAM
In the UK, the match will be available to watch live on television on Sky Sports 1 and by stream via Sky Go.
|UK TV channel||Online stream|
|Sky Sports 1||Sky Go|
In the US, the match will be available to watch live on television on NBC's Premier League Extra Time channel and by stream via NBC Sports Live.
|US TV channel||Online stream|
|NBC Premier League Extra||NBC Sports Live|
SQUADS & TEAM NEWS
|Position||West Ham players|
|Goalkeepers||Randolph, Adrian, Spiegel|
|Defenders||Reid, Cresswell, Collins, Ogbonna, Byram, Masuaku, Arbeloa, Fonte|
|Midfielders||Kouyate, Noble, Nordtveit, Feghouli, Fernandes, Lanzini, Snodgrass|
|Forwards||Carroll, Ayew, Calleri, Fletcher|
West Ham are waiting to see if Andy Carroll will be back after a groin injury and Arthur Masuaku (foot) is also a doubt, while Diafra Sakho has been ruled out for the season with a back problem.
Michail Antonio, Pedro Obiang and Gokhan Tore are also done for the campaign and Angelo Ogbonna is still working his way back from a knee injury.
|Goalkeepers||Lloris, Vorm, Lopez|
|Defenders||Walker, Rose, Alderweireld, Vertonghen, Trippier, Wimmer, Davies, Carter-Vickers|
|Midfielders||Son, Dier, Dembele, Dele, Eriksen, Wanyama, Onomah, Sissoko, Nkoudou, Edwards|
Mousa Dembele is expected to return for Tottenham after an ankle problem ruled him out of the north London derby, but Danny Rose will not be back in full training until next week as he continues his recovery from a knee injury.
Harry Winks and Erik Lamela are definitely out.
BETTING & GAME ODDS
Tottenham are 4/9 favourites to win away from home, according to Oddschecker, with West Ham priced at 15/2 and the draw available at 19/5.
Harry Kane is the 4/1 favourite to score first, with Dele Alli and Son Heung-Min rated at 5/1. Andy Carroll is the top choice for the hosts at 9/1.
There is no doubt that Chelsea's win over Everton was a defining one in the Premier League title race, coming as it did for the Blues against one of the division's hottest teams on their own turf.
It makes Tottenham's hopes of reeling in their London rivals look increasingly distant with four games remaining, three of which Antonio Conte's side will play at home. Two are against Sunderland and Middlesbrough, 20th and 19th in the table respectively.
In a way that takes some pressure off of Spurs, who can now think less about capitalising on any Chelsea slip-ups and simply focus on the game in front of them. They should have enough about them to make it 10 league wins in a row at West Ham, who are sleepwalking to the end of an enormously underwhelming campaign.
Then Chelsea will play at the weekend and Tottenham can see what happens.
There will be a tinge of disappointment as White Hart Lane hosts its final matches but Spurs could not have done much more. With a youthful, exciting side, they have collected more points in total - by some distance - than any other Premier League team over the past two seasons.
They have taken a step forward from their title challenge last season of the size that would usually deliver the trophy, but Chelsea have come flying back up the table and, so it seems, will deny them.
Perhaps Wembley will prove friendlier to them next season than it was in this year's Champions League. If they can keep this core intact, you would not bet against Spurs being right back up in the mix once again in 2018.