The Yellow Submarine have won this fixture in each of the previous two campaigns, while Atleti have only managed to score one goal in their last five matches against them.
bet365 offer Diego Simone's men at 21/20 (2.05) to record a victory at the Estadio de la Ceramica.
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Diego Costa and Kevin Gameiro both missed the trip to Russia and it remains to be seen whether they are available for Sunday's game.
Villarreal have Bruno Soriano still out, although his midfield partner Javi Fuego could return from an ankle injury.
Goals at a premium at the Estadio de la Ceramica
Villarreal have been a difficult side to predict this season, with Javi Calleja's men struggling for consistency.
Somehow, however, they always manage to perform against Atletico and meetings between these two sides are tight, well-organized affairs.
This can be seen in the fact that under 1.5 goals has paid out in six of their last eight meetings and a repeat is priced at a tempting 13/8 (2.62).
Tips and predictions
This selection has paid out in each of Villarreal's last five matches, as well as in nine of Atleti's last 12 games.
Furthermore, this has also proved a winning bet in ten of the last 12 meetings between the two teams.
Prices correct at time of writing. Please gamble responsibly.