Mauricio Pochettino's side will welcome the Hammers for what will be the hosts' second London derby at their new ground, and the Argentine will be keen for his side to make it two such wins on home soil.
With a Champions League semi-final in the not-too-distant future also weighing on their minds, Spurs will be keen to come through one of their last domestic games of the season unscathed as they enter the weekend with a three-point lead over fourth-place Chelsea.
Manuel Pellegrini will be hoping his side can shake off their recent malaise to become the first team to topple Tottenham in their sparkling new home, having seen his side go four games without a win now.
|Game||Tottenham vs West Ham|
|Date||Sunday, April 21|
|Time||12:30pm BST / 7:30am EST|
TV Channel, Live Stream & How To Watch
In the United States (US), the game can be watched live and on-demand
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|NBC Sports Live||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on Sky Sports Main Event and Sky Sports Premier League, and will be streamed on the Sky Go service.
|UK TV channel||Online |
Squads & Team News
|Goalkeepers||Lloris, Vorm, Gazzaniga|
|Defenders||Trippier, Rose, Alderweireld, Vertonghen, Sanchez, Walker-Peters, |
|Midfielders||Son, Wanyama, Eriksen, Lucas, Marsh, Skipp, Lamela, Alli|
Tottenham starting XI: Lloris;
|Position||West Ham squad|
|Defenders||Cresswell, Balbuena, Zabaleta, Ogbonna, Diop, Fredericks, Masuaku|
|Midfielders||Anderson, Lanzini, Snodgrass, Obiang, Sanchez, Noble, Rice, Antonio, Diangana, Johnson, Coventry, Holland|
|Forwards||Arnautovic, Chicharito, Perez, Silva|
West Ham starting XI: Fabianski; Fredericks, Diop, Balbuena, Masuaku; Snodgrass, Rice, Noble, Anderson; Antonio, Arnautovic
Betting & Match Odds
Tottenham are the odds-on favourites at 4/9 with bet365 to take the three points. West Ham
Though they may fall short once more in their quest for silverware this season, it's certainly been another strong campaign for Tottenham Hotspur and Mauricio Pochettino.
The Lilywhites currently sit third in the Premier League and though their title challenge has long since faded, they have proved once again to be one of the leading sides in English football thanks to both their domestic and international exploits.
Their surprise progress in the Champions League at the expense of Manchester City has also seen them reach the semi-finals of the competition for the first time this century, with them only two games from a trip to Madrid and the final.
With a three-point cushion over fourth-place Chelsea adding extra security their place in the top four of the top flight, their game against West Ham this weekend represents another chance to further cement their position.
The Hammers have only taken one point from their last four, albeit suffering defeats against Chelsea and Manchester United during that run.
If general pre-game talk has not been dominated by chatter about Tottenham's impending European date with destiny against Ajax, however, then it has been orientated around a former playmaker of the Dutch side whose future remains in question at Tottenham - Christian Eriksen.
The midfielder netted the winner against Brighton last time out and has 14 months left to run on his contract, but has so far been unable to
Pochettino remains hopeful that Eriksen will remain, though, while noting that he would rather delay such talks until after the end of the season.
"It is a very special situation," the Argentine stated. "Christian is a special person. I think we are all special, different and we need to understand that.
"The timing for him or for the club to be
"I think it is so close to the end of the season, [there is] a lot of time to talk after and I think the most important thing now, not only for him, is for all the players to be focused and try to achieve the things we want.
"We have a lot of big things ahead and we need to be focused only to try and recover, train and compete."