Kane has scored five goals in his last seven fixtures for club and country, and is 888Sport's 15/4 (4.75) favourite to open the scoring at Wembley.
Meanwhile, Hazard has scored five times in 11 appearances against Spurs, and is available at 31/20 (2.55) to add to his league tally for the season that currently stands at seven - one more than Kane.
Five of those seven league strikes have broken the deadlock, meaning 23/5 (5.60) first goalscorer odds look particularly appealing in this clash.
While he has struggled to match the Belgian's dazzling form so far this campaign, Alvaro Morata has shown signs of improvement after scoring four times in his last five league appearances, and can be backed at 39/20 (2.95) to strike once again.
Morata will still have to compete for a place in the side with Olivier Giroud, who is available at 41/20 (3.05) to open his Premier League account for the season in the week he moved above Zinedine Zidane into fourth in France's all-time top scorer list.
With five goals to his name in the last four games against Chelsea in all competitions, Dele Alli could offer strong value at 3/1 (4.00) - although he has only scored once in 12 matches so club and country.
In fact, the usually goal-shy Erik Lamela is Tottenham's second top scorer behind Kane, and is on offer at 4/1 (5.00) to score a seventh of the season in all competitions.