The Swans' new Portuguese boss Carlos Carvalhal will shake hands with compatriot Nuno Espirito Santo for a third time in 32 days after the two also met when the former’s Sheffield Wednesday side lost 1-0 to Wolves in December.
Wolves were odds-on to win the first clash but are now available at the more reasonable price of 2/1 (3.0) with bet365 for victory inside the 90 minutes.
Their hosts, though, have had a solid start to life under Carvalhal with just one loss in four games, and are 29/20 (2.45) for a second win under the 52-year-old's tutelage.
Both teams followed up the stalemate in the cup with another draw in the league – Wolves had a goalless encounter with Barnsley while the Swans drew 1-1 at Newcastle - a third straight tie for both outfits to bring about an extra time period is 5/2 (3.5).
Swansea midfielder Leroy Fer was sent off in the previous FA Cup encounter but had it retrospectively overturned and is 4/1 (5.0) to score anytime. Also free to play is right-back Kyle Naughton, who returns from a three-match ban, but Renato Sanches could miss out through a hamstring injury.
Visiting centre-back Danny Batth returns from a three-match ban and could be given some match practice, but left wing-back Ruben Vinagre’s suspension means Barry Douglas is likely to start.
Clean sheet for the visitors?
Wolves defenders Ryan Bennett and Conor Coady were among five first-team players to keep their place in the reverse fixture, while goalkeeper Will Norris has not conceded in any of the five cup games he has played in.
The Midlanders have kept 13 clean sheets in their last 19 games in all competitions while their hosts have failed to score 12 times this season – no Premier League outfit has done so more often. With that in mind, a clean sheet for the visitors looks appealing at 9/4 (3.25).
Bony and Mir to threaten?
With Tammy Abraham still out, Wilfried Bony is likely to start as Swansea’s main striker and the powerful Ivorian is 21/10 (3.1) to bag at any point.
For the away side, striker Leo Bonatini has not quite reached his own very high standards in recent weeks and with promotion to the Premier League surely a priority, January addition Rafael Mir could be given a chance to make his mark up top and is 13/5 (3.6) to score anytime.
Tips and predictions
With all that in mind, the 9/2 (5.5) price on a Wolves win with under 2.5 goals is too good to pass up.
There is every chance of the visitors keeping a clean sheet in south Wales, yet their attack is not quite as ruthless as we have seen earlier in the season; six of their last 10 victories have come by a 1-0 or 2-0 scoreline.
By contrast, Swansea look organized under Carvalhal but remain lacking in creativity and will be without arguably their best attacking player in Abraham.
Odds correct at the time of writing. Please gamble responsibly.