Sissoko has enjoyed a renaissance this season, going from one of Spurs' most-maligned players to perhaps one of their most important.
An excellent display against Crystal Palace at the weekend helped Mauricio Pochettino's men to a 1-0 win at Selhurst Park, while he also enjoyed a productive performance in the 3-2 win over Wolves.
Indeed, the Frenchman earned a recall to the national team following a series of selections in the club's starting XI - he has been involved in Tottenham's last six encounters - with the north London side currently fourth in the Premier League.
And Sissoko insists that he and his team-mates can challenge for the title.
"Every season, this league becomes more difficult, but we have to stick together and play our game, and do the right things to try and hopefully get something at the end of the season," he told reporters.
"But we have the quality to answer them."
Spurs have four points from their opening four Champions League group games, and sit three behind the Italian giants, to whom they lost in their opening European game.
However, a win over Inter may not guarantee qualification, as they may also need to defeat Barca in the final game of the campaign, though the encounter will take place at Camp Nou.