Real Madrid know their season hinges on the Champions League final on 26th May, meaning their trip south is less than important than it would have been in past seasons.
Sevilla have won their last two home La Liga matches against Real Madrid and bet365 offer another victory at 13/10 (2.30). Los Blancos, for their part, are priced at 8/5 (2.60) with the draw available at 3/1 (4.00).
Watch and bet live on Sevilla v Real Madrid
bet365 customers in the UK can watch and bet live on this fixture. Your account must be funded or active (have placed a bet in the last 24 hours) to enjoy the action.
Real Madrid are likely to field a much changed starting eleven, with Cristiano Ronaldo almost certain to be given the night off for the game with the side against whom he has scored more goals than any other.
Over the last few seasons this has been one of the most entertaining and goal-filled fixtures in the Spanish top flight.
The last ten La Liga meetings between these two sides have produced 48 goals, while this season Real Madrid's matches have averaged more goals than any other side.
Despite the fact Zidane likely to rest players, there should still be goals in this game and Los Blancos' record of two clean sheets in their last 15 matches will give Sevilla confidence in the final third.
Tips and predictions
Both teams to score is priced at 4/11 (1.44) but much more appealing is backing goals at both ends in the opening 45 minutes.
Both teams to score in the first half is priced at 9/4 (3.25) and has paid out in two of Madrid's last three league trips to Sevilla.
The European champions have conceded first half goals in five of their last seven matches and this looks like a great value selection for Wednesday night's game.
Prices correct at the time of writing. Please gamble responsibly.