Porto were unbeaten through the group stages against the likes of Galatasaray FC Schalke and Lokomotiv Moscow before being pitted against AS Roma in the Round of 16. The Italian side were beaten 4-3 on aggregate after the second leg went into extra-time.
Porto have been a resourceful team and have scored 18 goals in the Champions League so far.
Malian forward Moussa Marega has been the star for them with six goals while Mexican winger Jesus Corona has chipped in with three.
They will now hope to pull an upset over Liverpool in the quarter-final.