Los Rojiblancos have a much greater recent European pedigree than their French opponents, with two recent Champions League finals under their belt as well as those victories in this tournament.
Marseille, meanwhile, have also lost five matches in the tournament this season and they are two contributing factors as to why the La Liga outfit are such clear favourites.
The draw, which would lead to 30 minutes of extra time and potentially penalties, can be backed at 14/5 (3.80) .
The only potential injury concern for Atletico is winger Vitolo, who missed the weekend win over Getafe but trained on Monday and could be available.
Their opponents have doubts over striker Kostas Mitroglou and centre-back Rolando.
Marseille's journey to the final has been erratic to say the least, with Rudi Garcia's men needing an extra time goal from Rolando to send them through against Salzburg in the semi-final.
Not only have the Ligue 1 outfit lost five times in the Europa League this term, they have also failed to score in five matches and against arguably Europe's best defensive unit, they could struggle once more.
Atletico's defensive record in La Liga is extraordinary, with the Madrid outfit having conceded just 20 goals in 37 games.
Jan Oblak is making a strong case for being the world's best goalkeeper and across La Liga and the Europa League this term, the Slovenian stopper has kept a stunning 26 clean sheets.
Tips and predictions
Backing another clean sheet for Atletico appeals, and the price of 11/8 (2.38) for the Spanish side to win to nil looks like being a smart way to back them.
For higher odds, backing Simeone's side to win and under 2.5 goals at 11/5 (3.20) could also be an interesting value option.