Jose Mourinho's side have seen their title challenge fade over the festive period, for they have taken just two points from their Premier League fixtures against Leicester City and Burnley respectively.
United, though, are strong favourites to make a return to winning ways this weekend, with dabblebet offering just 2/5 (1.40) that the men from Manchester take all three points.
Southampton are struggling for form, particularly away from home where they have now gone seven Premier League matches without victory; the Saints suffered a humiliating 5-2 defeat at the hands of Tottenham Hotspur on Boxing Day and they will be desperate to avoid a similar fate when they travel to Old Trafford.
The odds compilers, though, are anticipating at tough 90 minutes for Mauricio Pellegrino's men and, indeed, dabblebet offer 15/2 (8.50) that the side from Hampshire pick up three precious points, while the same firm go 15/4 (4.75) that the match remains all square when these two teams lock horns.
Potential for goals
Manchester United have conceded at least twice in each of their last three matches and Mourinho's men will aim to stop the rot by keeping the Saints out; attaining that objective, though, will not be easy, for Southampton have scored in seven of their last eight matches in this competition, while each of those seven matches has seen goals at both ends.
United have scored in each of their last 10 outings and dabblebet go even money (2.0) that both teams are on target. The respective Boxing Day fixtures of these rivals produced no fewer than 11 goals and dabblebet's 8/11 (1.73) quote for two three or more to be scored on this occasion could well prove popular, while the same firm go 17/10 (2.70) that there are at least four strikes.
Can United shut out Saints?
Despite the defensive frailties that have been exposed in recent weeks, Manchester United boast a relatively strong defensive record on their own patch. Mourinho's side have kept a clean sheet in seven of their 10 Premier League matches on home soil and they can be backed at 17/20 (1.85) with dabblebet to do so again here.
Furthermore, Manchester United ran out as 1-0 winners when these last locked horns at St Mary's back in September; dabblebet offer even money (2.0) that there are fewer than three goals in this occasion while the same firm go 11/2 (6.50) that Mourinho's men chalk up another 1-0 win.
Tips and predictions:
Confidence in the Southampton camp appears to be fragile and Pellegrino will be concerned at the cheap concession of those goals against Spurs at Wembley on Tuesday.
Mourinho's men look well-placed to make a return to winning ways, but Saints could make an impact against a United side that has leaked goals at an alarming rate in recent matches.
It is, therefore, dabblebet's 11/5 (3.20) quote for Manchester United to win a match featuring goals at both ends that could represent good value for punters ahead of Saturday's showdown at Old Trafford.