Victory against the Terriers would represent a 31st league win of the season and a new record for Pep Guardiola's men, who would also set the bar for points in a season at 96.
Furthermore, Manchester City require just two goals to surpass the record tally for Premier League goals in a single season, having scored 102 in the competition thus far this term.
City are, of course, massive favourites to take all three points against the team from West Yorkshire and dabblebet offer just 1/14 (1.07) that Guardiola's champions come out on top.
Huddersfield have won just one of their last seven fixtures and, with a trip to Stamford Bridge and a home match against Arsenal to come, David Wagner's charges remain in grave danger of relegation.
Victory here would see Town take a massive stride towards preserving their Premier League status, but the enormity of the task facing them is reflected by the 25/1 (26.0) quote for an away win.
The same firm go 10/1 (11.0) that Wagner's side pick up a precious point and become just the third side this term to avoid defeat at the Etihad.
Sergio Aguero and John Stones remain out whilst Kyle Walker and Vincent Kompany are doubtful.
Elias Kachunga (ankle) and Danny Williams (fractured fibula) will play no further part in the campaign for the Terriers, while Tom Ince is a major doubt.
Goals galore for free-scoring hosts?
City have scored 30 goals in their last nine Premier League matches at Etihad Stadium and dabblebet go just 4/9 (1.44) that the men from Manchester score at least three times.
This selection would have landed in seven of their last nine games at the venue and in 12 of their 17 home league matches this season.
Tips and predictions
Better value, though, could lie in backing at least four goals to be scored in this game; the 4/5 (1.80) selection would have paid dividends in all but two of City's last nine Premier League matches at Etihad Stadium.