Leicester City are the visitors to Anfield, with Claude Puel's Foxes looking to bloody the nose of another one of the big boys.
They have already beaten both Manchester City and Chelsea in recent weeks, but will have their work cut out as they seek to become the first visiting side to win at Anfield in the league since April 2017.
Liverpool beat Crystal Palace in a nervy encounter 10 days ago, and have won 20 of their 23 league fixtures so far this season. A 21st victory would be the perfect way to end a challenging January for Jurgen Klopp's men.
Here, Goal takes a look at everything you need to know ahead of Wednesday night's game...
Liverpool will make checks on a number of players ahead of the game.
Fabinho limped out of the Palace game with a hamstring issue, but returned to light training last week and could be fit to feature despite a bout of illness. Trent Alexander-Arnold (knee) is likely to miss out, but Gini Wijnaldum could be ready to return after missing out against Palace. Virgil van Dijk, who missed training through illness on Friday, should be fine to play.
Dejan Lovren will also be available after a hamstring problem.
Joe Gomez, Rhian Brewster and Alex Oxlade-Chamberlain are all sidelined.
Liverpool will be without James Milner, who will serve a one-match ban following his dismissal against Crystal Palace.
Liverpool Likely Line-Up
The big question for Liverpool surrounds who will play at right back, with Alexander-Arnold set to miss out, Milner suspended and Nathaniel Clyne having been loaned to Bournemouth.
Fabinho, if fit, could fill in having performed well there in the past for both Monaco and Brazil. Youngster Rafa Camacho, who made his Premier League debut as a late substitute against Palace, is another, less pedigreed option, while teenage Dutchman Ki-Jana Hoever could be considered.
In midfield, Wijnaldum's return should see him partner Jordan Henderson, with the final place between Xherdan Shaqiri and Naby Keita. Keita was preferred last time out but is yet to make his mark since his move from RB Leipzig.
Leicester team news
Leicester will check on the fitness of defender Harry Maguire, who suffered an injury in the Foxes' last game against Wolves.
Daniel Amartey is on the long-term absentee list.
TV Channel & Kick-Off Time
The fixture will be broadcast live in the UK on BT Sport 1, kick-off 8pm. Highlights can be found on Match of the Day, BBC One at 10.45pm.
In the United States, the game can be watched live on television on NBC Sports, kick-off 3pm ET.
Best Opta Match Facts
Liverpool have won their last three league games against Leicester – they last won four in a row against them between February 1987 and September 1996.
Leicester have lost six of their last seven away Premier League games against Liverpool (D1), with their last win at Anfield coming in May 2000 (2-0).
Liverpool haven’t lost any of their last 19 home midweek games in the Premier League (Tuesday, Wednesday, Thursday), winning 13 and drawing six since a 0-1 loss vs Fulham in May 2012.
Liverpool are unbeaten in their last 32 home Premier League games (W23 D9), the longest such run in the division since Man City went 37 without defeat between December 2010 and December 2012.
Liverpool are looking to win eight consecutive Premier League home games for the first time since March 2010. The Reds conceded as many goals in their last home league game against Crystal Palace as they had in their previous 15 at Anfield combined (3).
Leicester have lost each of their last 11 Premier League games against sides starting the day top of the table, conceding at least twice every time (27 in total) and netting just five in return. Their last such win came on January 31st 1998 at Manchester United.
This will be Liverpool’s 10th Premier League game as the side starting top this season, more than they’ve played in any other season in the competition (9 in 1996-97).
Leicester have lost their last two Premier League games – the eighth time they’ve lost consecutive league matches under Claude Puel. However, they’ve not lost three in a row in the competition since February 2017 under Claudio Ranieri (a run of five).
Only Andrew Cole (11) and Thierry Henry (8) have scored more Premier League goals against Liverpool than Leicester’s Jamie Vardy (7).
Liverpool’s Roberto Firmino has committed more fouls without receiving a single yellow or red card than any other Premier League player this season (30).