The Reds have not gone six without a victory since January 2011, and after surrendering two points late on against Bournemouth in midweek, they will want no further threats to their position in the top four.
With injuries ever escalating, though, Jurgen Klopp is restricted in the kind of personnel changes he can make on Saturday afternoon. There’s a few formation tweaks he can consider, but little in the way of experienced quality to add.
Sadio Mane's season is over due to meniscus damage in his left knee. The Senegal international will have to go under the knife to correct the problem.
“Sadio will, we’re pretty sure, need surgery," said Klopp. "We’re not 100 per cent sure when it will happen, but then it is clear his season is over.
“That’s what I expected, actually, when I saw the video after the game.
"I thought he was lucky in this situation that not more happened, but now we are close to the end of the season and that means it will be pretty much impossible that he will play again this season.
“But then he’ll have a long break and be ready for next season, so that’s the only good news.”
Adam Lallana [thigh] and Jordan Henderson [foot] remain sidelined, while fingers will be crossed that a heavily bruised Emre Can did not suffer any ill-effects after Wednesday's 2-2 draw.
Klopp explained: “Adam Lallana is better, much better, but is of course no option for the weekend because he is not in training.
"He feels good, he is on a good way, but the problem with this is it is kind of a shooting muscle – one you use mainly if you shoot.
“He feels nothing in the moment, but we will need a few more days for sure before we can have him back on the pitch. It is similar to Hendo.
“Hendo is also in a good way but we don’t know exactly when he can be part of training again."
Joel Matip couldn't start against Eddie Howe's side because of a back issue, but was introduced for Philippe Coutinho on 65 minutes.
The Brazilian felt sick at Anfield and the illness has kept him out of training sessions.
“Phil is still ill and was not at Melwood yesterday and he will not be here today,” added Klopp.
“He had a conversation with the doc and he feels much better, but it doesn’t look too good. We will have to see if we [can] bring him in tomorrow.
“Stoke is not too far away so we will give him all the time he needs, but it will be really close.”
The visitors have no suspension concerns, but Marko Arnautovic and Joe Allen are one booking away from a ban for accumulating cautions.
LIVERPOOL POTENTIAL STARTING LINE-UP
Klopp has discussed a change in formation ahead of the previous two games following Mane's injury, but with little time to work on such in training, he's avoided altering the system from the off.
The German did reference freshness in his post-match analysis on Wednesday, and with Stoke the third challenge in a week, he may need to tinker on those grounds.
If Matip suffered no further damage to his back after the 2-2 draw, he should return to the starting XI alongside Dejan Lovren.
Ben Woodburn could slot into the attack if Coutinho doesn't recover in time, with Daniel Sturridge sharper too having completed more sessions.
Trent Alexander-Arnold is an option across a number of positions, while Klopp has also spoken about playing James Milner further forward.
STOKE CITY TEAM NEWS
Jonathan Walters was missing from the 1-0 defeat to Burnley through injury, but given his record against Liverpool, Mark Hughes will be desperate to have him in the matchday squad.
Peter Crouch brushed off a knock to his knee to take a place on the bench in midweek, but will be targeting a start against his former club.
Xherdan Shaqiri should be fit enough to feature as Stoke attempt to end a sequence of three consecutive Premier League defeats.
"We're waiting on a few," said Hughes.
"Jon Walters wasn't able to play in mid-week due to a slight concussion but he's come through multiple checks ok.
"Shaqiri has trained and is available so that's good news.
"We've got a couple of issues with Marc Muniesa and Mame Diouf, bangs on knees, but they're down to train today."
Saturday's hosts have lost six of their last seven top-flight matches against Liverpool.
BEST OPTA MATCH FACTS
The Reds have won 4-1 in Jurgen Klopp’s two previous Premier League games against Stoke.
Jonathan Walters has scored six times against Liverpool in the Premier League, his favourite opponent to score against.
The Reds have kept just six clean sheets in Jurgen Klopp’s 30 Premier League away games so far; the same total they’d recorded in Brendan Rodgers’ last 12 away matches with the club.
TV COVERAGE & KICK-OFF TIME
Kick off is at 3pm BST and the match is not televised live in the UK.