Both sides have had a poor run this season, struggling to match their opponents in the league as well as other domestic competitions.
With about eight matches left to the conclusion of the season, the sugarcane farmers find themselves bottom of the table with 24 points, three off safety.
Muhoroni Team manager Jefferson Odongo is adamant that the team will not drop come to the end of the season.
"We are remaining with eight matches, and we want to win all of them, that is 24 points for us. If it happens that we slip, then 21 points, but we want to bag maximum points.
"We are treating every match as a final, starting with our game this weekend against Tusker FC, we will not give them space."
Tusker are already out of the title race after a poor season with coach George Nsimbe conceding that the title is out of reach.