Both countries are preparing to participate in this summer's World Cup, but Didier Deschamps' team will hope that their impressive home record will give them the edge in Paris.
Les Bleus have lost just one of their last 20 matches on home soil and they can be backed at 1/2 (1.50) to see off the South Americans here.
Jose Pekerman's side have come out on top in just one of their last six games and are considered as a 6/1 (7.0) chance to win in the French capital. bet365 also go 3/1 (4.0) that the match ends all square.
Karim Benzema and Aymeric Laporte have been left out by Deschamps, but Anthony Martial is back in the fold.
Both James Rodriguez and Radamel Falcao have shaken off injury concerns to take their place in Pekerman's squad.
Glut of goals?
Colombia have scored in all but one of their last 10 matches and the bet365 go 10/11 (1.91) that there are goals at both ends in Paris.
The same firm offer 17/20 (1.85) that this fixture produces at least three goals, a play that would have landed in four of France's last six home games.
Preview and predictions
France have a fine home record and bet365's 1/2 (1.50) quote for Deschamps' side to win looks to be a solid selection.
Better value, though, could lie in backing Les Bleus to win a match in which there are at least three goals scored at 11/8 (2.38); the selection would have landed in eight of France's last nine home wins.
Odds correct at time of writing. Please gamble responsibly.